Codomax

Re-engineering cellular stress responses to biomanufacture affordable and accessible proteins for health and nutrition Our Mission: To drive the cost-effective and scalable production of recombinant proteins that contribute to improved health and nutrition Our Vision: To sustainably produce therapeutics and alternative foods that are accessible and affordable to all populations for the betterment of global health and nutrition Our Technology: Our team discovered the mechanism by which cells respond to all types of stress by reprogramming their translational machinery for “just-in-time” production of proteins essential for stress survival. Leveraging this novel biological insight, we can successfully express difficult-to-produce proteins, improve yields in any cell line, and shorten processing times. The unique biology of stress-induced translational reprogramming is tailored to the specific target protein, cell line, reactor environment, and manufacturing scale. These intricacies cannot be addressed solely through predictive AI and necessitate systems-based measurements. Our proprietary Epi-MAX platform technology succeeds by tuning the biology of protein-expressing cell lines to the complete biomanufacturing process, resulting in increases in protein yields up to 25-fold, thus far. This success is attributed to our approach of enhancing translation through a comprehensive multi-omics analytical and informatics platform, which evaluates cell behavior during protein over-expression. Subsequently, we re-engineer the expression system at every level, from vector to cell line, to effectively enhance the yield of functional protein in response to the cell’s environmental conditions Our Applications: 1. Difficult-to-express proteins 2. Maintaining high protein yields as production scales 3. Strain engineering to leverage stress response mechanisms for enhanced functional recombinant protein synthesis 4. Tissue-specific expression of mRNA therapeutics 5. Gene therapy manufacturing: capsid assembly and payload expression