nCage Therapeutics

nCage Therapeutics is developing a novel synthetic protein cage based on the bacterial TRAP protein. Protein cages are synthetic virus-like particles (VLPs), that can be used to display biological material on their surface, or transport molecules such as nucleic acids or proteins into the interior of the cell. nCage's TRAP-cage Artificial Protein Cages are formed by multiple copies of modified or de novo protein components designed to form stable, hollow protein shapes. A unique feature of theTRAP-cage platform is programmable opening and closing of the cages. Therefore, cargo can be loaded into the interior of the cages and be released inside cells. Cargo can be proteins, peptides, nucleic acids or small molecule drugs. nCage Therapeutics focuses on Synthetic VLP Vaccines for stronger and more durable vaccines against respiratory diseases and Antibody Drug Conjugates (ADCs) for enhancing safety profile of the blockbuster anti-cancer drugs.